Tomonobu Hasegawa Selected Research

Disorders of Sex Development (Intersexuality)

5/2009	Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients.
1/2006	Mutational Analysis of Androgen Receptor (AR) Gene in 46,XY Patients with Ambiguous Genitalia and Normal Testosterone Secretion: Endocrinological Characteristics of Three Patients with AR Gene Mutations.

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Tomonobu Hasegawa Research Topics

Disease

15	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 02/2024 - 01/2004
14	Congenital Hypothyroidism (Cretinism) 05/2024 - 04/2009
11	Neoplasms (Cancer) 11/2021 - 01/2009
9	Penis agenesis 09/2019 - 01/2002
7	Hypogonadism (Hypergonadotropic Hypogonadism) 07/2022 - 12/2004
7	Antley-Bixler Syndrome Phenotype 01/2018 - 01/2005
6	Hypothyroidism 03/2023 - 10/2008
5	Hypoglycemia (Reactive Hypoglycemia) 12/2022 - 04/2012
4	Body Weight (Weight, Body) 12/2022 - 01/2007
4	Virilism (Virilization) 01/2021 - 05/2009
4	Adrenal Insufficiency (Adrenal Gland Hypofunction) 08/2020 - 01/2008
4	Adenoma (Adenomas) 01/2019 - 12/2011
4	Hypopituitarism (Sheehan's Syndrome) 04/2015 - 01/2012
3	Addison Disease (Addison's Disease) 10/2023 - 08/2017
3	Turner Syndrome (Turner's Syndrome) 01/2023 - 04/2012
3	Precocious Puberty 01/2023 - 01/2009
3	Combined Pituitary Hormone Deficiency 12/2022 - 12/2014
3	Hyperglycemia 12/2022 - 01/2017
3	Cushing Syndrome 01/2022 - 01/2010
3	Hyponatremia 01/2022 - 06/2011
3	Hyperplasia 03/2020 - 06/2012
3	Osteogenesis Imperfecta (Lobstein Disease) 11/2018 - 01/2012
3	Hypertension (High Blood Pressure) 08/2017 - 01/2014
3	Hyperaldosteronism (Conn Syndrome) 08/2017 - 01/2014
3	Cryptorchidism (Undescended Testes) 09/2016 - 08/2005
3	Hypospadias 09/2016 - 12/2006
3	Noonan Syndrome (Female Pseudo-Turner Syndrome) 07/2013 - 08/2002
3	Sudden Infant Death (SID) 01/2013 - 07/2009
2	Goiter 02/2024 - 11/2017
2	Dwarfism 12/2022 - 02/2015
2	Hypokalemia 12/2022 - 01/2014
2	Hypertrophy 12/2022 - 01/2014
2	Asphyxia (Suffocation) 08/2022 - 06/2002
2	Hyperkalemia 01/2022 - 01/2013
2	Nevus (Nevi) 01/2022 - 07/2013
2	Hypernatremia 04/2021 - 01/2007
2	Androgen-Insensitivity Syndrome (Testicular Feminization) 01/2021 - 01/2007
2	Thyroid Dysgenesis (Thyroid Agenesis) 11/2020 - 01/2015
2	Primary Hyperparathyroidism 10/2019 - 07/2016
2	Parathyroid Neoplasms (Parathyroid Neoplasm) 10/2019 - 01/2019
2	XX Disorders of Sex Development 46 (Female Pseudohermaphroditism) 01/2019 - 05/2009
2	Graves Disease (Basedow Disease) 01/2019 - 08/2017
2	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 12/2018 - 05/2009
2	Osteoporosis 11/2018 - 09/2016
2	Fever (Fevers) 01/2018 - 01/2007
2	Megalencephaly 04/2017 - 05/2014
2	Diabetes Mellitus 01/2017 - 01/2017
2	Liver Diseases (Liver Disease) 01/2017 - 05/2013
2	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome) 01/2017 - 01/2010
2	Cholestasis 03/2015 - 05/2013

Drug/Important Bio-Agent (IBA)

18	SteroidsIBA 10/2023 - 12/2004
15	Hormones (Hormone)IBA 02/2024 - 12/2004
11	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2022 - 12/2004
9	Growth Hormone (Somatotropin)IBA 12/2022 - 04/2012
9	Testosterone (Sustanon)FDA Link 12/2022 - 12/2004
6	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2023 - 12/2004
6	Transcription Factors (Transcription Factor)IBA 12/2022 - 04/2010
6	Adrenocorticotropic Hormone (ACTH)FDA Link 12/2022 - 12/2004
6	Dual OxidasesIBA 01/2022 - 01/2013
5	EnzymesIBA 02/2024 - 07/2003
5	SodiumIBA 01/2022 - 01/2007
5	Oxidoreductases (Dehydrogenase)IBA 04/2016 - 01/2005
4	AldosteroneIBA 12/2022 - 01/2013
4	SaltsIBA 01/2022 - 01/2013
4	Thyrotropin Receptors (Thyrotropin Receptor)IBA 01/2021 - 04/2009
4	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 07/2004
4	pregnanetrioloneIBA 04/2016 - 01/2004
3	Thyroid HormonesIBA 05/2024 - 10/2008
3	Thyroxine (Levothyroxine)FDA LinkGeneric 03/2023 - 11/2020
3	IodineIBA 03/2023 - 10/2008
3	GonadotropinsIBA 01/2023 - 12/2004
3	Estrogens (Estrogen)FDA Link 01/2023 - 08/2005
3	Glucose (Dextrose)FDA LinkGeneric 12/2022 - 04/2012
3	ReninIBA 12/2022 - 01/2013
3	Androstenedione (4 Androstene 3,17 dione)IBA 11/2022 - 01/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2002
3	AndrogensIBA 01/2018 - 01/2009
3	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 01/2017 - 03/2004
3	GlucocorticoidsIBA 09/2016 - 10/2013
3	IsotopesIBA 01/2013 - 07/2009
3	testosterone enanthate (Delatestryl)FDA LinkGeneric 07/2010 - 07/2002
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 05/2009 - 01/2005
2	CateninsIBA 02/2024 - 10/2023
2	Fibroblast Growth Factor-23IBA 08/2023 - 10/2015
2	Insulin-Like PeptidesIBA 12/2022 - 08/2013
2	21-deoxycortisolIBA 11/2022 - 01/2013
2	FludrocortisoneIBA 01/2022 - 11/2020
2	CatecholaminesIBA 11/2021 - 01/2018
2	Dihydrotachysterol (AT 10)IBA 01/2021 - 12/2018
2	Insulin (Novolin)FDA Link 01/2020 - 08/2013
2	AntibodiesIBA 01/2019 - 07/2009
2	Dihydrotestosterone (Androstanolone)IBA 01/2018 - 07/2006
2	Diazoxide (Hyperstat)FDA Link 01/2018 - 01/2017
2	Iodide Peroxidase (Deiodinase)IBA 11/2017 - 03/2016
2	alpha2 Subunit Collagen Type IIBA 07/2015 - 06/2014

Therapy/Procedure

20	Therapeutics 03/2023 - 07/2002
4	Adrenalectomy 08/2017 - 01/2010
2	Cesarean Section (Caesarean Section) 08/2022 - 06/2002
2	Thyroidectomy 06/2019 - 01/2019
2	Parathyroidectomy 01/2019 - 07/2016